Pharmacogenomics of Open-Angle Glaucoma
نویسندگان
چکیده
منابع مشابه
Pharmacogenomics of Open-Angle Glaucoma
Pharmacogenomics is an evolving research discipline in medicine. Within ophthalmology, the earliest candidate gene investigations have studied primary and secondary open-angle glaucoma (OAG), as well as normal tension glaucoma (NTG). At this time, pharmacogenomics data are not generally used to make clinical decisions. However, as we collect data from clinical trials, the role of pharmacogenomi...
متن کاملPrimary open-angle glaucoma
Primary open-angle glaucoma (POAG) is an idiopathic disorder in which the resistance to outflow through the trabecular meshwork gradually increases and the intraocular pressure (IOP) rises, causing irreversible damage to the optic nerve POAG is the second most common cause of vision loss in the U.S. Usually asymptomatic until advanced visual field loss has occurred; less than 50% of those...
متن کاملScreening for open-angle glaucoma.
Chronic (open-angle) glaucoma is a leading cause of new cases of blindness in the United States. This blindness is a result of increased intraocular pressure and deterioration of the optic nerve. Nearly 2 million Americans have glaucoma. "Ocular hypertension" is the term applied to elevation of the ocular pressure above 21 mm Hg. Glaucoma is defined as a group of diseases that have certain comm...
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purpose: the objective of this study was to identify possible risk factors associated with primary open-angle glaucoma (poag). methods: a case-control study included patients seen at rasoul-akram hospital ophthalmology clinic. cases were consecutive patients with confirmed unilateral or bilateral poag presented during the study period. controls were a random sample of all other patients aged 30...
متن کاملScreening of CYP1B1 Arg368His as predominant mutation in North Indian primary open angle glaucoma and juvenile onset glaucoma patients
In India, mutations in Cytochrome P450 (CYP1B1) are a predominant cause of not only primary congenital glaucoma (PCG) but also involved in primary open angle glaucoma (POAG) and juvenile onset glaucoma (JOAG). After ethical clearance, 100 POAG patients, 30 primary angle closure glaucoma (PACG) patients and 130 ethnically matched controls were recruited in this study. Genomic DNA was is...
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ژورنال
عنوان ژورنال: Current Pharmacogenomics and Personalized Medicine
سال: 2008
ISSN: 1875-6921
DOI: 10.2174/1875692110806020121